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6b, treatment with 5-aza-2’-deoxycytidine (5-aza), a DNMT inhibitor, did not restore the decrease in the cFLIP level induced by Gln deprivation
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IGF-1/−2 Blocking mAbs A third therapeutic approach is to target the IGF-1 and IGF-2 ligands directly, thereby inhibiting proliferative/anti-apoptotic signaling via IGF-1R and INSR-A and their hybrid receptors, without compromising the function of INSR-B or affecting insulin action [65, 66, 73]
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