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HIF-1α hydroxilated is associated to E3 ubiquitin ligase Von Hippel Lindau protein (VHLp) for its degradation, whereas in hypoxia condition stabilization and nuclear translocation occur, leading to oncogenes activation (192)
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167,168,169 Unlike other nucleic acid-based drugs, aptamers specifically recognize and bind target molecules, such as peptides, proteins, viruses, bacteria, and cells, relying on their unique three-dimensional conformation
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