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Liver-related The following symptoms may indicate copper accumulation in the liver: weakness feeling tired weight loss nausea vomiting loss of appetite itching jaundice, or yellowing of the skin edema, or the swelling of legs and abdomen pain or bloating in the abdomen spider angiomas, or visible branch-like blood vessels on the skin muscle cramps Many of these symptoms, such as jaundice and edema, are the same for other conditions like liver and kidney failure

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Briefly, 5-μm-thick FFPE tissue sections were baked for 3 hours at 60°C before loading into the BOND RX