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Estimates suggest that tobacco use causes about 80,000 cases of gastric cancer annually (11% of all estimated cases) ( 4 Oxidative stress in gastric cancer 4.1 Gastric carcinogenesis Under oxidative stress, increased ROS in cells may harm tissues and trigger carcinogenesis, especially in the gastrointestinal system ( Figure 3 )

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These distinctive immunomodulatory properties offer an important theoretical basis for the development of novel immunotherapeutic strategies