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Glutathione C10h17n3o6s Tripeptide Antioxidant Structural Chemical Stock Vector (Royalty Free) 1823581355 | Shutterstock

In studies of GPX5 knockout mice, we deduced that GPX5 is a way to maintain the integrity of sperm DNA function by removing excess H 2 O 2 , and these mice did not exhibit significant defects in the epididymis and sperm cells ( 2 O 2 scavengers was detected (Noblanc et al., 2012), proving that after SNGPX4 and GPX5 double knockouts, the epididymal tissues of mice produced oxidative stress responses, indicating that SNGPX4 and GPX5 play a role in maintaining the normal structure of the sperm nucleus in the epididymal tissue (Noblanc et al., 2012)

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Their combined treatment synergistically activates the Nrf2/Keap1 pathway, effectively blocking myoglobin-induced ferroptosis