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Daily oral doses of 800–2,000 IU (20–50 μg) for 2–3 months are recommended for adults with mild deficiency, while severe deficits are usually treated with higher doses (1,250 μg) once per week for 6–12 weeks, followed by a lower daily intake

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Methylphenidate (low-quality evidence, GRADE), which is primarily used in the clinical treatment of attention deficit hyperactivity disorder, has also been used in fatigue management in previous years