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This is where glutathione, a powerful pro-tumor nutrient that Harris has been studying for several years, came into focus

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The membrane-associated Ring-CH type finger 6 (MARCHF6) E3 ubiquitin ligase located in the endoplasmic reticulum contains a unique C-terminal binding region that can directly sense the levels of NADPH in the cytoplasm, thereby increasing the enzyme’s activity and leading to changes in the levels of critical regulators of ferroptosis, such as ACSL4 and p53 [150]