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EGb 761 (Ginkgo biloba) protects cochlear hair cells against ototoxicity induced by gentamicin via reducing reactive oxygen species and nitric oxide-related apoptosis
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This reaction serves as an anaplerotic reaction allowing for continued production of TCA intermediates such as 2-oxoglutarate (α-ketoglutarate) and citrate for continued energy production Despite the reduced level of oxidative phosphorylation due to NO-mediated inhibition of the PDHc, this process allows for the conservation of lactate and pyruvate for diversion into the gluconeogenesis pathway thereby supporting cellular growth and other anabolic pathways
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