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➡️Knuckle hyperpigmentation due to Vitamin B12 deficiency is a well-recognized (and often overlooked) clinical sign., ❓Why it happens, ➡️Vitamin B12 deficiency can cause increased melanin production ...
Notably, the mitochondrial enzyme citrate synthase (CS) condenses oxaloacetate and acetyl-CoA into citrate in the first step of the TCA cycle (Figure 1A)(95)
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doi:10.1016/bs.irn.2020.01.001
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