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NMR relaxation experiments for the recombinant L -version of the FOXO4-DRI sequence were recorded using 13 C, 15 N-labeled samples at 300 µM in a buffer containing 50 mM NaH 2 PO 4 /Na 2 HPO 4 , pH 6.5, 0.04 % NaN 3 , 2.5 mM DTT and 10 % D 2 O in the absence and in presence of 400 µM synthetic D -p53 TAD2 peptide using the same NMR parameters

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Mitochondrial function, which NAD precursors support, is fundamental to neuronal survival