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The topical-route human evidence consists of the Mulder 1994 multicenter RCT in diabetic neuropathic ulcers (industry-sponsored, evaluator-blinded) [11] , the Leyden 2002 AAD conference abstract (never published in a peer-reviewed journal), and the Miller 2006 split-face CO2-laser study, which reported no statistically significant benefit in blinded objective measures of erythema or wrinkle measurement [12]
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I doubt we’ll get another multi-million-dollar renovation, but one can hope
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