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Perspectives and challenges In recent years, the domain of epigenetics has undergone substantial expansion, incorporating a diverse array of mechanisms including nucleosome positioning, chromatin remodeling, histone modifications, DNA methylation, RNA modifications, alternative RNA splicing, and non-coding RNAs (such as lncRNAs, miRNAs, circRNAs, piRNAs, among others), as well as pseudogenes (non-coding DNA)
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The first-hand clinical experience accumulated from the most urgent rare severe disease areas will serve as the scientific foundation for building a broader pediatric application basis
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