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(Reference Nordestgaard, Thomsen and Nordestgaard37) did not include formal MR analysis, only regression of the coffee genetic risk score against the outcomes (common in early MR studies)
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In pulmonary artery hypertension which is caused by chronic hypoxia and often leads to right ventricular hypertrophy, several recent studies demonstrated a significant elevation of intracellular labile zinc levels in both pulmonary endothelial cells and vascular smooth muscle cells 65,66
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