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In vitro and clinical studies also reveal that vitamin C can enhance the efficacy of phagocytosis and pathogen killing by promoting neutrophil chemotaxis (47,48)
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For instance, chronic doxorubicin (DOX) intervention can also lead to cardiomyocyte aging, suggesting that the aging mechanism shares many irreversible stress factors with the cardiac injury pathway, such as decreased Sirtuins expression, increased p38 mitogen-activated protein kinases (p38MAPK) signaling, and decreased antioxidant enzyme levels represented by MnSOD [21, 22]
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