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IGF-1 LR3 binds the alpha subunit of the IGF-1 receptor tyrosine kinase, inducing autophosphorylation of the beta subunit on specific tyrosine residues (Y1131, Y1135, Y1136) that create docking sites for insulin receptor substrate (IRS) proteins and Shc adaptor proteins
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[9] Because B vitamins are water-soluble, excess amounts are excreted in urine, which can lead to a noticeable change in urine color
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