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In one compelling study of more than 400 participants over two years, there was a 15% difference in the occurrence of major adverse cardiovascular events.9 And a 2025 meta-analysis of 45 randomized controlled trials found that supplementation significantly reduced blood pressure without affecting heart rate.27 Statin pain Statins are medications that target cholesterol and triglycerides to prevent heart disease

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It is hypothesized that this results in a glutamate surge, ultimately agonizing postsynaptic AMPA-glutamate receptors and triggering production of brain-derived neurotrophic factor, which orchestrates synaptogenesis and neuroplasticity ( This cascade of events is believed to be responsible for the observed increase in global brain connectivity in the prefrontal cortex of individuals with MDD within 24 hours of a single ketamine infusion and imaged with functional connectivity MRI