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However, in a study using IL-6 knockout mouse, the severity of age-related OA in male mice was significantly increased, but not in female mice [73] suggesting that low levels of IL-6 may be required to maintain chondrocyte homeostasis and play a protective role at some stage, at least in age-related OA

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Nutrition strategies that support hormone balance and weight loss include: Keeping blood sugar stable with adequate protein at every meal and fiber-rich carbohydrates Including omega-3 fats and polyphenol-rich foods to reduce inflammatory responses Following a balanced diet that supports fat metabolism and hormone regulation Limiting processed sugar and alcohol, which directly spike cortisol Exercise strategies should include resistance training to support muscle building, lean muscle development, and metabolic health