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The results showed that HG treatment induced ferroptosis, as evidenced by increased expression of NCOA4 and TFR-1, and decreased expression of GPX4, SLC7A11, and FTH-1, which were reversed by Cur-NCs and Fer-1 treatment (Figures 2D, E)

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At this point, the plant synthesizes cellular AsA and GSH, which act as non-enzymatic antioxidants by involving their enzymatic components to detoxify ROS up to tolerable levels (Table 1)