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The combination of low-dose RSL3 and a PD-1 antibody significantly increased the complete response rate in melanoma (197) Notably, ferroptosis-induced immunoregulation involves epigenetic regulation: inhibition of apolipoprotein C1 (APOC1) can downregulate GPX4 activity (198), promote HMGB1 release through the MCP-UFM1-PIR axis, activate the HMGB1-RAGE-NF-κB signaling cascade (199), effectively trigger immunogenic ferroptosis, ultimately induce macrophage polarization towards the M1 type and enhance antigen presentation capacity, and produce a synergistic anti-tumor effect with PD-1 antibodies