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The key features that distinguish paraptosis from classical apoptosis include its independence from caspase-9 activation, the absence of typical apoptotic markers such as chromatin condensation or DNA laddering, and cytoplasmic vacuolisation as the predominant morphological feature positively modulated by the mitogen-activated protein kinase (MAPK) signalling pathway [119]
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[DOI] [PMC free article] [PubMed] [Google Scholar] 16.Mechanism of diabetic neuropathy: where are we now and where to go
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