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Innate immune cells such as neutrophils, monocytes, and NK cells may infiltrate the tumour as a result, and the phenotype of resident macrophages in the tumour microenvironment may be altered (Zheng et al., 2017)

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These included ki-67 labelling index (main end point), c-erB2 expression, apoptosis, and oestrogen and progesterone receptors

A number of reviewers reported positive experiences