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The evolution of obesity medicines captured in a single image. Semaglutide activates a single pathway (GLP-1). Tirzepatide engages two (GLP-1 + GIP). Retatrutide goes further with three — adding glucagon, which directly

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Heterogeneity was quantified using the I 2 statistic, with values of 25, 50, and 75% indicating low, moderate, and high heterogeneity, respectively (Nakagawa et al., 2017)