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Both antibodies induce cADPR consumption to increase ADPR production, consistent with a shift toward CD38 hydrolase activity and a 2–3‑fold rise in the ADPR/cADPR ratio

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“We are encouraged by the weight loss profile of CagriSema demonstrating superiority over both semaglutide and cagrilintide in monotherapy in the REDEFINE 1 trial,” Martin Holst Lange, executive vice president for development at Novo Nordisk, said in a statement

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