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There are alterations of GSH reductase activity in peripheral-blood erythrocytes in such diseases as hypothyroidism and riboflavin deficiency.73,74 Exhaustive physical exercise causes changes in the glutathione status of blood, liver and muscles.75 A recent study on Indian populations of different age groups revealed an agedependent decline in intracellular-reduced GSH concentration which correlates with the total antioxidant capacity of the plasma.42 Gil et al.47 reported a slow but significant decline of the intra erythrocytic GSH concentration with aging in European subjects