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Activated microglia secrete the chemokine CXCL2, which in turn upregulates ACSL4 expression and suppresses GPX4 activity in adjacent neurons, intensifying lipid peroxidation and membrane damage

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For each linear and logistic regression model, we performed sensitivity analyses by calculating E-values 70,71 , which provide estimates of the magnitude of unmeasured confounding that could explain the observed effects and have been recommended as a type of sensitivity analysis 70,72