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Superoxide released into the IMS can be eliminated by a different SOD isoenzyme (Cu, Zn-SOD, or SOD1), which is found in the cytoplasm of eukaryotic cells, or scavenged by cytochrome c plus cytochrome c oxidase system (Okado-Matsumoto and Fridovich, 2001)
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Ehrick JD et al, “Considerations for the development of nasal dosage forms” in “Sterile Product Development” (Kolhe P, Shah M,Rathore N, eds)
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