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Gene knockdown experiments further confirmed that the absence of Nox4 inhibits the TGF-ฮฒ/SMAD signaling pathway and reduces the transcription of fibrosis-related genes, suggesting that the Nox4-ROS-TGF-ฮฒ axis plays a crucial role in the stromal-epithelial interaction in PCa (27, 28)
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[DOI] [PubMed] [Google Scholar] 108.Tsuiji K., Takeda T., Li B., Wakabayashi A., Kondo A., Kimura T., Yaegashi N
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