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RCSB PDB - 1GNW: STRUCTURE OF GLUTATHIONE S-TRANSFERASE

In the early phase, histamine and serotonin are released, causing vasodilation while in the late phase, other chemicals become active: bradykinin, prostaglandins, neutrophil-derived ROS, nitric oxide, cytokines, proteases and lysososmal enzymes [12]

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Demonstrates 69–85% sensitivity depending on reference standards and is particularly effective for early autonomic neuropathy detection [33, 34]