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Mass isotopologue distributions (MIDs), representing the incorporation of 13 C-labeled substrates into metabolites (from m + 0 to m + n, where n is the maximum number of carbon atoms), revealed a higher incorporation of 13 C from [U- 13 C]-glucose in all the glycolytic intermediates of MEC-1/N M cells, confirming that NOTCH1 hyperactivation increases glycolytic flux