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50 A recent spatial transcriptomics study demonstrated that the increased presence of macrophages in the diseased tendon resulted in alterations to the microenvironment of TDSCs, thereby promoting their differentiation into bone and cartilage formation

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In activated T cells, metabolic fitness and synthetic function has been directly linked to G6PD activity and ROS homeostasis by Ghergurovich and colleagues, who used a novel metabolite reporter and deuterium tracer assays to monitor cellular G6PD activity in the presence of a specific potent inhibitor of G6PD (55)