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FDA Advisory No. 2017 192. | PDF
Conclusions There is a strong relationship between nutritional deficiencies and disease
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Future efforts should prioritize the development of robust experimental models, both in vitro and in vivo, taking advantage of immunocompetent models and single-cell and spatial multiomics technologies, alongside innovative tissue and liquid biopsies to monitor MRD, to accelerate the dynamic tracking and therapeutic exploitation of the DTP phenotype, with the ultimate goal of inducing long-lasting clinical responses in patients with cancer
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