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Other indexes of lipid peroxidation, such as F 2 -isoprostanes, are easier to detect by mass spectrometry (30–32) and result from peroxidation of arachidonic acid [20:4], which, as mentioned above, is rich in brain
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In fact, the opposite occurred: not only was an EPR spectrum observed, but Aβ42Y10F was as toxic to rat hippocampal neuronal cultures and led to their oxidative damage to a similar extent as observed with native human Aβ42 (111, 112, 115)
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