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Nootropics and neurorestoratives graded by the evidence | NeuroAge Blog
Results GSTM1 shares maximum homology with GSTM2 In our structural homology analysis, the members of the GST superfamily were found to share high sequence homology with each other when examined by ClustalW ( and a domain search using Pfam ( Members of the same class ( i.e ., other GSTΞΌ enzymes) share 75β99% sequence identity (maximum homology between GSTM1 and GSTM2 ), whereas the homology is approximately 25β30% with different classes ( GSTΞΈ and GSTΟ )
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Furthermore, multiple studies indicate that various natural plant bioactive compounds can reverse tumor multidrug resistance by downregulating Pβgp expression on tumor cell membranes, offering a potential strategy to overcome clinical chemotherapy resistance [9, 258, 276]
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