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322 Mechanistically, the SIRT6-mediated antioxidant effect by H3K56ac deacetylation activated the Nrf2-mediated antioxidant gene
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Administration of riddelliine, a naturally occurring pyrrolizidine alkaloid, to rats results in cytomegaly and karyomegaly of hepatic endothelial cells as one of its pleotrophic responses to cell-specific cytotoxicity
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