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This is also consistent with earlier studies showing that cystine starvation activates GCN2 rather than PERK 47 and the lack of enhanced splicing of the XBP1 mRNA upon erastin treatment 9
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Moreover, GZMA can enhance the transcriptional activity of GPx4, inhibit ferroptosis, promote intestinal epithelial cell differentiation, and improve the function of the intestinal barrier by activating the cAMP/PKA/CREB signaling pathway
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